One of the most deleterious effects of ''normal'' aging is impaired glucose metabolism. Failure to control excess sugar can trigger a cascade of ill health effects throughout the body. For example, patients with high blood sugar can suffer after-meal endothelial dysfunction, induced by a flood of glucose, fats, and abnormal proteins called advanced glycation end products entering the bloodstream.

Benfotiamine, a fat-soluble form of vitamin B1 (thiamine), may help your body to support healthy blood sugar metabolism. It acts through several mechanisms to seemingly block the biochemical pathways by which high blood sugar wreaks havoc throughout the body. In a study published in the journal Diabetes Care, scientists demonstrated for the first time that benfotiamine (1050 mg per day) effectively reduced postprandial endothelial dysfunction and oxidative stress normally seen in patients with high blood sugar who were fed a heat-processed meal with a high content of advanced glycation end products.

Mega Benfotiamine may help maintain already-normal blood sugar levels and support the health of the nerves, kidneys, eyes, blood vessels, and heart. Mega Benfotiamine 250mg (S-benzyolthiamine-O-monophosphate) is a synthetic derivative of thiamin (Vitamin B1), belonging to the family of compounds known as “allithiamines."

Benfotiamine is fat-soluble and more bioavailable and physiologically active than thiamin. Benfotiamine is reported to raise the blood level of thiamin pyrophosphate (TPP), the biologically active coenzyme of thiamin, and stimulate transkotelase, a cellular enzyme essential for maintenance of normal glucose metabolic pathways.

References:

http://www.ncbi.nlm.nih.gov/pubmed/24643695 http://www.ncbi.nlm.nih.gov/pubmed/24399744 http://www.ncbi.nlm.nih.gov/pubmed/23091724 Nat Med. 2003 Mar;9(3):294-9. Diabetes Care 2006;29:2064-71.